Melanocyte Stem Cell Maintenance and Hair Graying
نویسندگان
چکیده
Hair graying is an obvious sign of human aging, yet little was known about its causes. Two recent papers provide compelling evidence that hair graying is due to incomplete melanocyte stem cell maintenance and identify Pax3 and Mitf as key molecules that help regulate the balance between melanocyte stem cell maintenance and differentiation.
منابع مشابه
Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche.
Hair graying is the most obvious sign of aging in humans, yet its mechanism is largely unknown. Here, we used melanocyte-tagged transgenic mice and aging human hair follicles to demonstrate that hair graying is caused by defective self-maintenance of melanocyte stem cells. This process is accelerated dramatically with Bcl2 deficiency, which causes selective apoptosis of melanocyte stem cells, b...
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ورودعنوان ژورنال:
- Cell
دوره 121 شماره
صفحات -
تاریخ انتشار 2005